ABO/Secretor genetic complex and susceptibility to asthma in childhood

A positive association has recently been reported in adult subjects between O/nonSecretor phenotype and asthma. To confirm this association, this study investigated the joint ABO/Secretor phenotype in a cohort of 165 asthmatic children. Three-hundred and sixty-two consecutive newborn infants from th...

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Published inThe European respiratory journal Vol. 17; no. 6; pp. 1236 - 1238
Main Authors Ronchetti, F, Villa, M.P, Ronchetti, R, Bonci, E, Latini, L, Pascone, R, Bottini, N, Gloria-Bottini, F
Format Journal Article
LanguageEnglish
Published Leeds Eur Respiratory Soc 01.06.2001
Maney
Subjects
ABO Blood-Group System - genetics
Adolescent
Asthma - genetics
Biological and medical sciences
Child
Child, Preschool
Chronic obstructive pulmonary disease, asthma
Female
Fucosyltransferases - genetics
Galactoside 2-alpha-L-fucosyltransferase
Genetic Predisposition to Disease - genetics
Humans
Infant
Male
Medical sciences
Phenotype
Pneumology
Rome
Rome
Human
Respiratory disease
Secretion
Oligosaccharide
ABO(H)-System
Exploration
Asthma
Blood group
Phenotype
Gene
Risk factor
Obstructive pulmonary disease
Child
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Summary:A positive association has recently been reported in adult subjects between O/nonSecretor phenotype and asthma. To confirm this association, this study investigated the joint ABO/Secretor phenotype in a cohort of 165 asthmatic children. Three-hundred and sixty-two consecutive newborn infants from the same population were also studied as controls. The proportion of O/nonSecretor in asthmatic children was higher than in controls, thus confirming the association found in adults. The association was more marked in males than in females. In males, the pattern of association between the joint ABO/Secretor phenotype and asthma is dependent on the age at on-set of symptoms. Since the oligosaccharide composition of cell membrane and mucosal secretions is controlled by the cooperative interaction of ABO and Secretor genes, and since such composition influences the adhesion of infectious agents, the age pattern could reflect a more general interaction between developmental maturation and oligosaccharide structure concerning their effects on susceptibility to viral and bacterial agents.
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ISSN:0903-1936
1399-3003
DOI:10.1183/09031936.01.99109101