"Clickable", polymerized liposomes as a versatile and stable platform for rapid optimization of their peripheral compositions

A versatile and stable liposomal platform is developed for rapid optimization of its peripheral composition. The platform is based on polydiacetylene lipids terminated with alkynyl groups. Conditions for copper-catalyzed azide-alkyne cycloaddition (a "click" reaction) are optimized for rap...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 46; no. 31; pp. 5746 - 5748
Main Authors Kumar, Amit, Erasquin, Uriel J, Qin, Guoting, Li, King, Cai, Chengzhi
Format Journal Article
LanguageEnglish
Published England 21.08.2010
Subjects
Alkynes - chemistry
Animals
Attachment
Azides - chemistry
Catalysis
Cell Line, Tumor
Copper - chemistry
Cycloaddition
Lipids
Liposomes
Liposomes - chemistry
Microscopy, Fluorescence
Optimization
Platforms
Polyacetylenes - chemistry
Polydiacetylenes
Polymerization
Polymers - chemistry
Rats
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Summary:A versatile and stable liposomal platform is developed for rapid optimization of its peripheral composition. The platform is based on polydiacetylene lipids terminated with alkynyl groups. Conditions for copper-catalyzed azide-alkyne cycloaddition (a "click" reaction) are optimized for rapid attachment of azides with controlled composition onto the liposomes.
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ISSN:1359-7345
1364-548X
DOI:10.1039/c0cc00784f