Bone-specific alkaline phosphatase - a potential biomarker for skeletal growth assessment

• Published in: Journal of orthodontics Vol. 45; no. 1; p. 4
• Main Authors: Tripathi, Tulika, Gupta, Prateek, Sharma, Jitender, Rai, Priyank, Gupta, Vinod Kumar, Singh, Navneet
• Format: Journal Article
• Language: English
• Published: England 01.03.2018
• Subjects: Alkaline Phosphatase; Biomarkers; Cervical Vertebrae; Cross-Sectional Studies; Female; Humans; Insulin-Like Growth Factor I; Male; Biomarkers; IGF-1; bone-specific alkaline phosphatase; skeletal growth
• ISSN: 1465-3133
• DOI: 10.1080/14653125.2017.1416571

The present study was aimed to assess levels of serum Bone-specific alkaline phosphatase (BALP) and serum Insulin-like growth factor-1 (IGF-1) and comparing with cervical vertebral maturation index (CVMI) stages. Cross-sectional study. Maulana Azad Institute of Dental Sciences, New Delhi, India. 150 subjects (75 males and 75 females) in the age group of 8-20 years. Subjects were divided into six CVMI stages. Enzyme-linked immunosorbant assay was performed for the estimation of serum BALP and serum IGF-1 levels. Mann-Whitney U test was performed to compare mean ranks of serum BALP and serum IGF-1 with different CVMI stages. Spearman correlation between serum BALP and serum IGF-1 was done across 6 CVMI stages. Peak serum IGF-1 levels were found at CVMI stages 4 and 3 for males and females respectively. Peak levels for serum BALP were found at stage 3 for both genders with significant differences from other stages. A statistically significant correlation was seen between serum IGF-1 and serum BALP from CVMI stages 1 to 3 and 4 to 6 (p < .01). BALP showed promising results and can be employed as a potential biomarker for the estimation of growth status.