Future trials of endovascular mechanical recanalisation therapy in acute ischemic stroke patients - A position paper endorsed by ESMINT and ESNR Part II: methodology of future trials

• Published in: Neuroradiology Vol. 54; no. 12; pp. 1303 - 1312
• Main Authors: Fiehler, Jens, Söderman, Michael, Turjman, Francis, White, Philip M., Bakke, Søren Jacob, Mangiafico, Salvatore, von Kummer, Rüdiger, Muto, Mario, Cognard, Christophe, Gralla, Jan
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.12.2012; Springer
• Subjects: Biological and medical sciences; Brain Ischemia - diagnosis; Brain Ischemia - therapy; Clinical Trials as Topic - standards; Endpoint Determination; Europe; Forecasting; Human viral diseases; Humans; Imaging; Infectious diseases; Intracranial Thrombosis - diagnosis; Intracranial Thrombosis - therapy; Investigative techniques, diagnostic techniques (general aspects); Invited Review; Medical sciences; Medicin och hälsovetenskap; Medicine; Medicine & Public Health; Nervous system; Neuroimaging - standards; Neurology; Neuroradiology; Neurosciences; Neurosurgery; Patient Selection; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Radiography, Interventional; Radiology; Research Design - standards; Societies, Medical; Stents; Stroke - diagnosis; Stroke - therapy; Technology Assessment, Biomedical; Thrombectomy - instrumentation; Thrombectomy - methods; Thrombolytic Therapy - standards; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Europe; Stroke; Thrombectomy; Thrombolysis; Interventional neuroradiology; Nervous system diseases; Methodology; Radiodiagnosis; Cardiovascular disease; Endovascular route; Cerebral disorder; Vascular disease; Treatment; Ischemia; Central nervous system disease; Patient position; Cerebrovascular disease
• ISSN: 0028-3940; 1432-1920; 1432-1920
• DOI: 10.1007/s00234-012-1076-y

Based on current data and experience, the joint working group of the European Society of Minimally Invasive Neurological Therapy (ESMINT) and the European Society of Neuroradiology (ESNR) make suggestions on trial design and conduct aimed to investigate therapeutic effects of mechanical thrombectomy (MT). We anticipate that this roadmap will facilitate the setting up and conduct of successful trials in close collaboration with our neighbouring disciplines.