The potential importance of HIV-induction of lymphocyte homing to lymph nodes

The mechanism by which HIV causes depletion of CD4 lymphocytes remains unknown. Recent studies have demonstrated that HIV binding to resting CD4 lymphocytes causes them to home from the blood into lymph node, and during the homing process, they are induced into apoptosis only to secondary signals th...

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Published inInternational immunology Vol. 11; no. 10; pp. 1591 - 1594
Main Authors Chen, Jenny J.-Y., Cloyd, Miles W.
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.10.1999
Subjects
AIDS
AIDS/HIV
Apoptosis - immunology
CD4 antigen
Cell Adhesion - immunology
HIV
HIV - immunology
HIV - physiology
HIV Infections - immunology
HIV Infections - virology
homing
Human immunodeficiency virus
Humans
Immunity, Cellular
lymph nodes
Lymph Nodes - immunology
Lymph Nodes - physiology
Lymph Nodes - virology
lymphocytes
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Summary:The mechanism by which HIV causes depletion of CD4 lymphocytes remains unknown. Recent studies have demonstrated that HIV binding to resting CD4 lymphocytes causes them to home from the blood into lymph node, and during the homing process, they are induced into apoptosis only to secondary signals through the homing receptors. If this is the principal mechanism of CD4 cell depletion, it can explain many of the events known to occur in HIV-infected individual.
Bibliography:PII:1460-2377
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Miles W. Lloyd
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ObjectType-Review-3
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ISSN:0953-8178
1460-2377
DOI:10.1093/intimm/11.10.1591