Case report: Incidence and prognostic value of brain MRI lesions and elevated cerebrospinal fluid protein in children with Guillain-Barré syndrome

• Published in: Frontiers in neurology Vol. 13
• Main Authors: Pizzo, Francesco, Di Nora, Alessandra, Di Mari, Alessia, Costanza, Giuseppe, Testa, Elisabetta, Strazzieri, Marianna, Greco, Filippo, Timpanaro, Tiziana, Basile, Antonio, Belfiore, Giuseppe, Giugno, Andrea, Rocca, Roberta, Ruggieri, Martino, Fiumara, Agata, Pavone, Piero
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 21.10.2022
• Subjects: childhood; clinical outcome; CSF; Guillain–Barré syndrome; MRI; Neurology; neurology-clinical
• ISSN: 1664-2295; 1664-2295
• DOI: 10.3389/fneur.2022.885897

Background Guillain-Barrè syndrome (GBS) is an acute immune-mediated disorder affecting peripheral nerves and nerve roots with a variable clinical course and outcome. Epidemiologic analyses have revealed that the incidence of the syndrome increases linearly among the age. The clinical diagnosis of GBS is based on the family history, physical and neurological examination, electrodiagnostic exams, and cerebrospinal fluid analysis with the classical presence of albumin-cytologic dissociation. Prognosis is associated with the severity of clinical signs and the type of peripheral nerves involved. Methods This study aims to clarify which clinical features can be used for prognostic purposes. We evaluated the correlation between (1) brain MRI lesions and grade of disability; (2) brain MRI lesions and elevated cerebrospinal fluid (CSF) protein; and (3) increased levels of CSF protein and grade of disability. Statistical analysis extracted from these data indicated a good correlation to be a prognostic indicator in children affected by GBS. We found little evidence regarding laboratory tests, imaging, and prognosis. We enrolled 12 continuous patients who met the Brighton criteria for GBS in this retrospective study. Each patient was clinically evaluated at the time of disease onset to assess the GBS disability score and after 2 weeks. Results We estimated Pearson's correlation index to evaluate the possible correlation between MRI and disability and CSF protein levels and disability. The correlation coefficient was 0.92 and 0.85, respectively. In addition, we developed a graph to see the trend of the disability values, proteins in the CSF, and damage assessed with MRI in the 12 patients. It seems that these parameters have a parallel trend and a good correlation in each patient. Finally, we calculated the correlation between MRI and CSF protein values, with an r -value of 0.87. The values suggest a correlation among the MRI score, CSF protein, and prognosis. Conclusion The MRI and CSF laboratory parameters can be important tools for the clinician not only for diagnosis but also to evaluate the possible worsening of general conditions or the need to prepare measures to support life parameters. Patients who need ventilatory support could be established early from patients who have less severe GBS and can begin rehabilitation earlier. We suggest MRI should be performed routinely in children with GBS to be able to estimate the evolution of the clinical condition.