Research Progress on the Molecular Mechanism of Polymorph Nucleation in Solution: A Perspective from Research Mentality and Technique

Based on the importance of polymorphic regulation, the molecular mechanism of nucleation has been widely concerned. This review begins by introducing the development and limitations of nucleation theory for organic small molecule crystals, followed by a summary of the general research mentality adop...

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Bibliographic Details
Published inCrystals (Basel) Vol. 13; no. 8; p. 1206
Main Authors Shi, Peng, Han, Ying, Zhu, Zhenxing, Gong, Junbo
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.08.2023
Subjects
Carbon
Crystal defects
Crystal structure
crystallization
mechanism
molecular route
Nucleation
phase change
polymorph
Polymorphism
Simulation methods
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Summary:Based on the importance of polymorphic regulation, the molecular mechanism of nucleation has been widely concerned. This review begins by introducing the development and limitations of nucleation theory for organic small molecule crystals, followed by a summary of the general research mentality adopted by current researchers. Moreover, the progress of the molecular mechanism of polymorphic nucleation and its application to the regulation of crystal forms are discussed. In addition, the development of scientific tools for the study of the molecular mechanism of polymorphic nucleation is also summarized, including experimental characterization and computational simulation, providing reference for relevant researchers. Finally, according to the main defects of current research and research ideas, research models and development directions of prospects and recommendations are put forward.
ISSN:2073-4352
2073-4352
DOI:10.3390/cryst13081206