Chromosomal evidence for the transplantability of the Shay chloroleukemia

Chloroma cells, which were shown to contain the X and Y chromosomes, were used to induce Shay chloroleukemia (SCL) in female recipients. Karyotype analyses of leukemic myeloblasts which appeared in the peripheral blood of the female recipients during blast crisis demonstrated invariably the presence...

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Bibliographic Details
Published inJournal of surgical oncology Vol. 10; no. 5; p. 441
Main Authors Derelanko, M J, Moorthy, A S, LoBue, J, Meagher, R C, Gordon, A S, Mitra, J, Fredrickson, T N
Format Journal Article
LanguageEnglish
Published United States 1978
Subjects
Animals
Female
Leukemia, Experimental - etiology
Leukemia, Experimental - genetics
Leukemia, Myeloid - etiology
Leukemia, Myeloid - genetics
Male
Neoplasm Transplantation
Rats
Retroviridae
Transplantation, Homologous
X Chromosome
Y Chromosome
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Summary:Chloroma cells, which were shown to contain the X and Y chromosomes, were used to induce Shay chloroleukemia (SCL) in female recipients. Karyotype analyses of leukemic myeloblasts which appeared in the peripheral blood of the female recipients during blast crisis demonstrated invariably the presence of the X and Y chromosomes. These results directly demonstrate that transmission of SCL is the result of donor cell colonization and therefore SCL can be considered a true transplantable leukemia. Reports by other workers of viral association with this disease are discussed in light of our results.
ISSN:0022-4790
DOI:10.1002/jso.2930100509