Hepatocellular carcinoma in young, mentally retarded HBsAg carriers without cirrhosis

In a Californian institution for the mentally retarded, surveillance by autopsy of all deaths (n = 138) identified three cases of hepatocellular carcinoma. Hepatocellular carcinoma cases occurred in young (mean age = 26 years) male carriers of HBsAg and were not associated with cirrhosis. They were...

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Published inHepatology (Baltimore, Md.) Vol. 5; no. 5; p. 824
Main Authors Lohiya, G, Pirkle, H, Hoefs, J, Lohiya, S, Ngo, V T
Format Journal Article
LanguageEnglish
Published United States 01.09.1985
Subjects
Adult
Carcinoma, Hepatocellular - immunology
Carcinoma, Hepatocellular - pathology
Carrier State - immunology
Hepatitis B - immunology
Hepatitis B Surface Antigens - analysis
Humans
Intellectual Disability - immunology
Liver Cirrhosis
Liver Neoplasms - immunology
Liver Neoplasms - pathology
Male
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Summary:In a Californian institution for the mentally retarded, surveillance by autopsy of all deaths (n = 138) identified three cases of hepatocellular carcinoma. Hepatocellular carcinoma cases occurred in young (mean age = 26 years) male carriers of HBsAg and were not associated with cirrhosis. They were of the nonfibrolamellar oncocytic type and were rapidly fatal. Hepatocellular carcinoma incidence in HBsAg carriers was estimated to be 246 times greater than United States males.
ISSN:0270-9139
1527-3350
DOI:10.1002/hep.1840050519