The Role of Different Scinderin Domains in the Control of F-Actin Cytoskeleton during Exocytosis

• Published in: Annals of the New York Academy of Sciences Vol. 971; no. 1; pp. 248 - 250
• Main Authors: LEJEN, T., PENE, T. DUMITRESCU, ROSÉ, S. D., TRIFARÓ, J-M.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.10.2002
• Subjects: Actins - metabolism; Animals; Binding Sites; Cell Membrane - metabolism; Chromaffin Cells - metabolism; Cytoskeleton - metabolism; Cytosol - metabolism; Exocytosis; F-actin; Gelsolin; Microfilament Proteins - chemistry; Microfilament Proteins - physiology; Microscopy, Confocal; Protein Structure, Tertiary; scinderin (Sc); Transfection

: Scinderin (Sc), a Ca2+‐regulated actin‐binding protein, has been previously shown to control submembranous actin dynamics in regulated secretion. The results of the present study suggest the possibility that Sc might act as a molecular switch in the control of cortical F‐actin dynamics during secr...