The Role of Different Scinderin Domains in the Control of F-Actin Cytoskeleton during Exocytosis

: Scinderin (Sc), a Ca2+‐regulated actin‐binding protein, has been previously shown to control submembranous actin dynamics in regulated secretion. The results of the present study suggest the possibility that Sc might act as a molecular switch in the control of cortical F‐actin dynamics during secr...

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Published inAnnals of the New York Academy of Sciences Vol. 971; no. 1; pp. 248 - 250
Main Authors LEJEN, T., PENE, T. DUMITRESCU, ROSÉ, S. D., TRIFARÓ, J-M.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.10.2002
Subjects
Actins - metabolism
Animals
Binding Sites
Cell Membrane - metabolism
Chromaffin Cells - metabolism
Cytoskeleton - metabolism
Cytosol - metabolism
Exocytosis
F-actin
Gelsolin
Microfilament Proteins - chemistry
Microfilament Proteins - physiology
Microscopy, Confocal
Protein Structure, Tertiary
scinderin (Sc)
Transfection
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Summary:: Scinderin (Sc), a Ca2+‐regulated actin‐binding protein, has been previously shown to control submembranous actin dynamics in regulated secretion. The results of the present study suggest the possibility that Sc might act as a molecular switch in the control of cortical F‐actin dynamics during secretion.
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ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2002.tb04469.x