Cell therapies for liver diseases

Cell therapies, which include bioartificial liver support and hepatocyte transplantation, have emerged as potential treatments for a variety of liver diseases. Acute liver failure, acute‐on‐chronic liver failure, and inherited metabolic liver diseases are examples of liver diseases that have been su...

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Bibliographic Details
Published inLiver transplantation Vol. 18; no. 1; pp. 9 - 21
Main Authors Yu, Yue, Fisher, James E., Lillegard, Joseph B., Rodysill, Brian, Amiot, Bruce, Nyberg, Scott L.
Format Journal Article
LanguageEnglish
Published Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.01.2012
Subjects
Animals
Cell- and Tissue-Based Therapy - methods
Disease Models, Animal
Hepatocytes - transplantation
Humans
Liver Diseases - therapy
Liver, Artificial
Stem Cell Transplantation - methods
Swine
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Summary:Cell therapies, which include bioartificial liver support and hepatocyte transplantation, have emerged as potential treatments for a variety of liver diseases. Acute liver failure, acute‐on‐chronic liver failure, and inherited metabolic liver diseases are examples of liver diseases that have been successfully treated with cell therapies at centers around the world. Cell therapies also have the potential to be widely applied to other liver diseases, including noninherited liver diseases and liver cancer, and to improve the success of liver transplantation. Here we briefly summarize current concepts of cell therapy for liver diseases. Liver Transpl 18:9–21, 2012. © 2011 AASLD.
Bibliography:This research was supported by the Marriott Foundation, the Coulter Foundation, Yecuris Corporation, and the National Institutes of Health (R01‐DK56733, R41 DK092105).
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ISSN:1527-6465
1527-6473
DOI:10.1002/lt.22467