Deletion of a common region on the long arm of chromosome 6 in acute lymphoblastic leukaemia

We have characterised a region of deletion on the long arm of chromosome 6 (6q) in six cases of acute lymphoblastic leukaemia, by fluorescence in situ hybridisation, using a series of YAC clones which map to 6q. Conventional cytogenetic analysis of four of these cases had been interpreted as showing...

Full description

Saved in:
Bibliographic Details
Published inGenes chromosomes & cancer Vol. 10; no. 1; p. 26
Main Authors Menasce, L P, Orphanos, V, Santibanez-Koref, M, Boyle, J M, Harrison, C J
Format Journal Article
LanguageEnglish
Published United States 01.05.1994
Subjects
Adolescent
Adult
Child
Child, Preschool
Chromosome Deletion
Chromosomes, Artificial, Yeast
Chromosomes, Human, Pair 6
Female
Humans
In Situ Hybridization, Fluorescence
Male
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
Online AccessGet more information

Cover

More Information
Summary:We have characterised a region of deletion on the long arm of chromosome 6 (6q) in six cases of acute lymphoblastic leukaemia, by fluorescence in situ hybridisation, using a series of YAC clones which map to 6q. Conventional cytogenetic analysis of four of these cases had been interpreted as showing terminal deletions of 6q. We demonstrated by FISH that in all cases the deletions were interstitial. D6S246 (6q16.3) was the only marker which was missing in all six cases, indicating a common region of deletion between the markers M6P1 at 6q14-15 and FYN at 6q21. Our results suggest the presence of a tumour suppressor gene within this interval.
ISSN:1045-2257
DOI:10.1002/gcc.2870100105