Acute hepatitis A infection in hepatitis B chimpanzee carriers

Two hepatitis B virus carrier chimpanzees which were superinfected with hepatitis A virus developed acute hepatitis followed by the production of antibodies to hepatitis A virus. The Southern blot technique employed to monitor liver hepatitis B virus DNA revealed that the amount of viral DNA in both...

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Bibliographic Details
Published inHepatology (Baltimore, Md.) Vol. 4; no. 3; p. 504
Main Authors Tsiquaye, K N, Harrison, T J, Portmann, B, Hu, S, Zuckerman, A J
Format Journal Article
LanguageEnglish
Published United States 01.05.1984
Subjects
Animals
Carrier State
DNA, Viral - analysis
Female
Hepatitis A - complications
Hepatitis A - pathology
Hepatitis A - veterinary
Hepatitis B - complications
Hepatitis B - pathology
Hepatitis B - veterinary
Hepatitis B Surface Antigens - analysis
Hepatitis B virus - genetics
Hepatitis, Viral, Animal - complications
Liver - pathology
Nucleic Acid Hybridization
Pan troglodytes
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Summary:Two hepatitis B virus carrier chimpanzees which were superinfected with hepatitis A virus developed acute hepatitis followed by the production of antibodies to hepatitis A virus. The Southern blot technique employed to monitor liver hepatitis B virus DNA revealed that the amount of viral DNA in both animals was significantly reduced during the acute phase of hepatitis A infection. The levels of plasma hepatitis B DNA polymerase activity were also reduced in one chimpanzee. The high titers of HBsAg in the circulation remained unchanged throughout the study, and antibodies to the surface antigen and to e antigen were not detected. The morphological lesions in the liver were severe in one chimpanzee from whom one specimen showed both periportal focal necrosis and zonal parenchymal necrosis.
ISSN:0270-9139
1527-3350
DOI:10.1002/hep.1840040325