Synthesis and Potent Antimicrobial Activity of Some Novel 4-(5, 6-Dichloro-1H-benzimidazol-2-yl)-N-substituted Benzamides

• Published in: Archiv der Pharmazie (Weinheim) Vol. 337; no. 10; pp. 556 - 562
• Main Authors: Ozden, S, Karatas, H, Yildiz, S, Goker, H
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.10.2004; WILEY‐VCH Verlag; Wiley; Wiley-VCH
• Subjects: 1H-Benzimidazole; Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antifungal agents; Antifungal Agents - chemical synthesis; Antifungal Agents - chemistry; Antifungal Agents - pharmacology; Antifungal and Antibacterial Activity; Benzamide; Benzamides - chemical synthesis; Benzamides - chemistry; Benzamides - pharmacology; Biological and medical sciences; Candida albicans; Candida albicans - drug effects; Chemistry; Chemistry, Medicinal; Chemistry, Multidisciplinary; Enterococcus faecalis; Enterococcus faecalis - drug effects; Escherichia coli; Escherichia coli - drug effects; Life Sciences & Biomedicine; Medical sciences; Methicillin Resistance; Methicillin-resistant Staphylococcus aureus; Methicillin-resistant Staphylococcus epidermidis; Microbial Sensitivity Tests; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Physical Sciences; Science & Technology; Staphylococcus aureus; Staphylococcus aureus - drug effects; Staphylococcus epidermidis - drug effects; Structure-Activity Relationship; benzamide; antifungal and antibacterial activity; H-benzimidazole; ANTIBACTERIAL; Turkey methicillin-resistant staphylococcus aureus; methicillin-resistant staphylococcus; BENZIMIDAZOLES; epidermidis; In vitro; Antifungal and Antibacterial Activity; Benzamide; Antimicrobial agent; Meticillin; Resistance; Antifungal agent; Amine; Staphylococcus epidermidis; Structure activity relation; Benzimidazole derivatives; Chlorine Organic compounds; Methicillin-resistant Staphylococcus aureus; Bacteria; Micrococcales; Benzamide derivatives; Micrococcaceae; Antibacterial agent; Chemical synthesis; Staphylococcus aureus; 1H-Benzimidazole; Methicillin-resistant Staphylococcus epidermidis
• ISSN: 0365-6233; 1521-4184
• DOI: 10.1002/ardp.200400884

A series of 4‐(5, 6‐dichloro‐1H‐benzimidazol‐2‐yl)‐N‐substituted benzamides were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, methicillin‐resistant S. aureus (MRSA), methicillin‐resistant S. epidermis (MRSE), Enterococcus faecalis, Escherichia coli and Candida albicans. Certain compounds inhibit bacterial growth with low MIC values (μg/mL). Among them, compounds 10 and 11 exhibited the greatest antibacterial activity with MIC values of 3.12 μg/mL against S. aureus, MRSA and MRSE.