Variation in executive function relates to BMI increases in youth who were initially of a healthy weight in the ABCD Study

• Published in: Obesity (Silver Spring, Md.) Vol. 31; no. 11; pp. 2809 - 2821
• Main Authors: Adise, Shana, Ottino‐Gonzalez, Jonatan, Goedde, Lauren, Marshall, Andrew T., Kan, Eric, Rhee, Kyung E., Goran, Michael I., Sowell, Elizabeth R.
• Format: Journal Article
• Language: English
• Published: United States 01.11.2023
• Subjects: Adolescent; Body Mass Index; Child; Cognition; Executive Function; Humans; Obesity; Weight Gain
• ISSN: 1930-7381; 1930-739X
• DOI: 10.1002/oby.23811

Objective The study aim was to determine whether (A) differences in executive function (EF) and cognition precede weight gain or (B) weight gain causes changes to EF and cognition. Methods Data were gathered from the Adolescent Brain Cognitive Development (ABCD) Study (release 4.0; ages 9–12 years old [N = 2794]; 100% had healthy weight at baseline [i.e., 9/10 years old], 12.4% had unhealthy weight by ages 11/12 years). EF and cognition were assessed across several domains (e.g., impulsivity, inhibitory control, processing speed, memory); BMI was calculated from height and weight. Nested random‐effects mixed models examined (A) BMI ~ EF × Time (i.e., variation in EF/cognition precedes weight gain) and (B) EF ~ BMI × Time (weight gain causes changes to EF/cognition) and controlled for sex, puberty, and caregiver education; random effects were site and subject. Results Variation in impulsivity, memory, learning, and processing speed was associated with greater increases in BMI trajectories from 9 to 12 years old. Weight gain was associated with a decrease in inhibitory control, but no other associations were observed. Conclusions Underlying variation in EF and cognition may be important for weight gain, but 2 years of weight gain may not be enough to have clinical implications for EF and cognition beyond inhibitory control. These findings suggest that more attention should be paid to the inclusion of EF programs in obesity prevention efforts.