Effect of food on the bioavailability of captopril in healthy subjects

14C-Captopril was administered as 100-mg tablets to 12 subjects in a two-way crossover study in which subjects were either fasted or were given a standard meal immediately prior to dosing. Based on blood level and urinary excretion data, both the absorption of total radioactivity and the bioavailabi...

Full description

Saved in:
Bibliographic Details
Published inJournal of clinical pharmacology Vol. 22; no. 2-3; p. 135
Main Authors Singhvi, S M, McKinstry, D N, Shaw, J M, Willard, D A, Migdalof, B H
Format Journal Article
LanguageEnglish
Published England 01.02.1982
Subjects
Adolescent
Adult
Biological Availability
Biotransformation
Captopril - administration & dosage
Captopril - metabolism
Feces - analysis
Food
Humans
Male
Proline - analogs & derivatives
Time Factors
Online AccessGet more information

Cover

More Information
Summary:14C-Captopril was administered as 100-mg tablets to 12 subjects in a two-way crossover study in which subjects were either fasted or were given a standard meal immediately prior to dosing. Based on blood level and urinary excretion data, both the absorption of total radioactivity and the bioavailability of captopril were decreased approximately 35 to 40 per cent after a meal. Whether this moderate decrease in the absorption and the bioavailability of captopril caused by food is of clinical significance has not yet been determined.
ISSN:0091-2700
DOI:10.1002/j.1552-4604.1982.tb02661.x