Integrated Analysis of a Noncoding RNA-Associated Competing Endogenous RNA Network in Non-Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Dysregulation of both coding and long noncoding RNAs (lncRNAs) plays crucial role in the pathogenesis and development of the disease. In this study, we identified a profile of dysregulated RNAs using datase...

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Bibliographic Details
Published inIEEE access Vol. 8; pp. 88977 - 88989
Main Authors Hao, Fengjie, Shi, Junfeng, Chen, Yongjun, Gu, Xuefeng, Ma, Di
Format Journal Article
LanguageEnglish
Published Piscataway IEEE 2020
The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subjects
Annotations
Biological activity
ceRNA network
Diseases
Functional analysis
Heating systems
Liver
Liver diseases
lncRNA
miRNA
mRNA
Non-alcoholic fatty liver disease
Pathogenesis
RNA
Volcanoes
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Summary:Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Dysregulation of both coding and long noncoding RNAs (lncRNAs) plays crucial role in the pathogenesis and development of the disease. In this study, we identified a profile of dysregulated RNAs using datasets from a public database. By incorporating all interactions between different RNAs, a competing endogenous RNA network was established to further illustrate the regulatory roles of noncoding miRNAs and lncRNAs. Moreover, a functional analysis showed that NAFLD is more closely associated with certain biological processes and pathways. Altogether, these results provide a helpful perspective on NAFLD and may assist future diagnosis and treatment of the disease.
ISSN:2169-3536
2169-3536
DOI:10.1109/ACCESS.2020.2992109