Cell injury triggers actin polymerization to initiate epithelial restitution

• Published in: Journal of cell science Vol. 131; no. 16
• Main Authors: Aihara, Eitaro, Medina-Candelaria, Neisha M, Hanyu, Hikaru, Matthis, Andrea L, Engevik, Kristen A, Gurniak, Christine B, Witke, Walter, Turner, Jerrold R, Zhang, Tongli, Montrose, Marshall H
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Ltd 15.08.2018
• Subjects: Actins - metabolism; Animals; Cell Movement; Cells, Cultured; Epithelial Cells - physiology; Female; Gastric Mucosa - injuries; Gastric Mucosa - metabolism; Gastric Mucosa - physiology; Male; Mice; Mice, Transgenic; Organoids - cytology; Organoids - injuries; Organoids - physiology; Polymerization; Protein Multimerization - physiology; Re-Epithelialization - physiology; Regeneration - physiology; Stomach - cytology; Stomach - injuries; Epithelial cell; Gastric organoid; Repair; Actin; Cell migration

The role of the actin cytoskeleton in the sequence of physiological epithelial repair in the intact epithelium has yet to be elucidated. Here, we explore the role of actin in gastric repair and gastric organoids (gastroids). In response to two-photon-induced cellular damage of either an gastric or g...