Congenital Hypopituitarism

Mutations of growth hormone genes and pituitary transcription factors account for a small proportion of cases of severe congenital hypopituitarism. Most cases show characteristic MRI findings of pituitary stalk interruption syndrome. Clinical suspicion should prompt assessment of cortisol, free T4,...

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Bibliographic Details
Published inClinics in perinatology Vol. 45; no. 1; p. 75
Main Author Parks, John S
Format Journal Article
LanguageEnglish
Published United States 01.03.2018
Subjects
Hypopituitarism
MRI
Pituitary stalk
Growth hormone
Hypoglycemia
Cholestasis
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Summary:Mutations of growth hormone genes and pituitary transcription factors account for a small proportion of cases of severe congenital hypopituitarism. Most cases show characteristic MRI findings of pituitary stalk interruption syndrome. Clinical suspicion should prompt assessment of cortisol, free T4, thyroid-stimulating hormone, and growth hormone levels together with MRI of the hypothalamic and pituitary regions.
ISSN:1557-9840
DOI:10.1016/j.clp.2017.11.001