Reinterpreting the human ABR binaural interaction component: isolating attention from stimulus effects

• Published in: Hearing research Vol. 410; p. 108350
• Main Authors: Ikeda, Kazunari, Campbell, Tom A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2021
• Subjects: Acoustic Stimulation; Auditory brainstem response binaural interaction component (ABR-BIC); Click; Evoked Potentials, Auditory, Brain Stem; Humans; Individuality; Monaural; Selective attention; Tone; Selective attention; Click; Monaural; Auditory brainstem response binaural interaction component (ABR-BIC); Tone
• ISSN: 0378-5955; 1878-5891
• DOI: 10.1016/j.heares.2021.108350

•Attention to tone-pips or clicks increases the effect size of the presence of DN1.•Such selective attention to tone-pips, but not clicks, affected ABR wave Vs.•There were isolable attention-independent stimulus effects upon DN1 amplitudes.•The mediation of that stimulus effect on DN1 differs from that on binaural wave V. Subtracting the sum of left and right monaural auditory brainstem responses (ABRs) from the corresponding binaural ABR isolates the binaural interaction component (ABR-BIC). In a previous investigation (Ikeda, 2015), during auditory yet not visual tasks, tone-pips elicited a significant difference in amplitude between summed monaural and binaural ABRs. With click stimulation, this amplitude difference was task-independent. This self-critical reanalysis's purpose was to establish that a difference waveform (i.e., ABR-BIC DN1) reflected an auditory selective attention effect that was isolable from stimulus factors. Regardless of whether stimuli were tone-pips or clicks, effect sizes of the DN1 peak amplitudes relative to zero improved during auditory tasks over visual tasks. Auditory selective attention effects on the monaural and binaural ABR wave-V amplitudes were tone-pip specific. Those wave-V effects thus could not explain the stimulus-universal effect of auditory selective attention on DN1 detectability, which was thus entirely binaural. In a manner isolated from auditory selective attention, multiple mediation analyses indicated that the higher right monaural wave-V amplitudes mediated individual differences in how clicks, relative to tone-pips, augmented DN1 amplitudes. There are implications of these findings for advancing ABR-BIC measurement.