Preferential Homing of Tumor-specific and Functional CD8+ Stem Cell-like Memory T Cells to the Bone Marrow

• Published in: Journal of immunotherapy (1997) Vol. 42; no. 6; p. 197
• Main Authors: Wu, Kang, Li, Yongchao, Zhang, Shaoying, Zhou, Nan, Liu, Bingfeng, Pan, Ting, Zhang, Xu, Luo, Haihua, Huang, Zhaofeng, Li, Xuefeng, Zhang, Hui, Zhang, Junsong
• Format: Journal Article
• Language: English
• Published: United States 01.07.2019
• ISSN: 1537-4513
• DOI: 10.1097/CJI.0000000000000273

The bone marrow (BM) harbors not only hematopoietic stem cells but also conventional memory T and B cells. Studies of BM-resident memory T cells have revealed the complex relationship between BM and immunologic memory. In the present study, we identified CD122 stem cells antigen-1 (Sca-1), B-cell lymphoma protein-2 (Bcl-2), CD8 stem cell-like memory T cells (TSCMs) as a distinct memory T-cell subset preferentially residing in the BM, where these cells respond vigorously to blood-borne antigens. We found that the most TSCMs favorably relocate to the BM by adhesion molecules such as vascular cell adhesion protein 1, P-selectin glycoprotein 1, and P-selectin or E-selectin. Moreover, the BM-resident TSCMs exhibited much higher levels of antitumor activity than the spleen-resident TSCMs. These results indicate that the BM provides an appropriate microenvironment for the survival of CD8 TSCMs, thereby broadening our knowledge of the memory maintenance of antigen-specific CD8 T lymphocytes. The present findings are expected to be instructive for the development of tumor immunotherapy.