Treatment strategies for esophageal cancer

The treatment of esophageal cancer has evolved considerably in the past decade and depends largely on the extent of disease at the time of presentation. For disease confined to the esophageal mucosa, endoscopic therapy is replacing esophagectomy as the standard of care. For locoregional disease, neo...

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Bibliographic Details
Published inGastroenterology clinics of North America Vol. 42; no. 1; p. 187
Main Authors Nieman, Dylan R, Peters, Jeffrey H
Format Journal Article
LanguageEnglish
Published United States 01.03.2013
Subjects
Adenocarcinoma - pathology
Adenocarcinoma - therapy
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - therapy
Chemoradiotherapy
Combined Modality Therapy
Esophageal Neoplasms - pathology
Esophageal Neoplasms - therapy
Esophagectomy - methods
Humans
Neoadjuvant Therapy
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Summary:The treatment of esophageal cancer has evolved considerably in the past decade and depends largely on the extent of disease at the time of presentation. For disease confined to the esophageal mucosa, endoscopic therapy is replacing esophagectomy as the standard of care. For locoregional disease, neoadjuvant chemoradiation followed by esophagectomy is the best strategy for optimizing long-term survival. In the minority of patents who present with metastatic disease, the prognosis is poor. Palliative therapies available for these patients include chemotherapy, radiation, endoscopic therapies to ameliorate obstruction or bleeding, and surgical intervention to optimize nutritional status or to relieve obstruction.
ISSN:1558-1942
DOI:10.1016/j.gtc.2012.11.007