Neurotrophin regulation of neural circuit development and function

Brain-derived neurotrophic factor (BDNF)--a member of a small family of secreted proteins that includes nerve growth factor, neurotrophin 3 and neurotrophin 4--has emerged as a key regulator of neural circuit development and function. The expression, secretion and actions of BDNF are directly contro...

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Published inNature reviews. Neuroscience Vol. 14; no. 1; pp. 7 - 23
Main Authors Park, Hyungju, Poo, Mu-ming
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.01.2013
Subjects
Animals
Brain - cytology
Brain - growth & development
Brain - metabolism
Brain-Derived Neurotrophic Factor - physiology
Humans
Nerve Net - physiology
Neurons - metabolism
Synapses - physiology
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Summary:Brain-derived neurotrophic factor (BDNF)--a member of a small family of secreted proteins that includes nerve growth factor, neurotrophin 3 and neurotrophin 4--has emerged as a key regulator of neural circuit development and function. The expression, secretion and actions of BDNF are directly controlled by neural activity, and secreted BDNF is capable of mediating many activity-dependent processes in the mammalian brain, including neuronal differentiation and growth, synapse formation and plasticity, and higher cognitive functions. This Review summarizes some of the recent progress in understanding the cellular and molecular mechanisms underlying neurotrophin regulation of neural circuits. The focus of the article is on BDNF, as this is the most widely expressed and studied neurotrophin in the mammalian brain.
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ISSN:1471-003X
1471-0048
1469-3178
DOI:10.1038/nrn3379