NEGotiating Cell Identity through Regulated Cytoplasmic Polyadenylation

In this issue of Developmental Cell, Elewa et al. (2015) show that combinatorial action of RNA binding proteins modulates poly(A) tail length of maternal mRNAs, leading to asymmetric expression of a cell fate determinant in early C. elegans embryos. Genome-wide profiling suggests this mechanism may...

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Bibliographic Details
Published inDevelopmental cell Vol. 34; no. 1; pp. 1 - 2
Main Authors Joshi, Pradeep M., Rothman, Joel H.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 06.07.2015
Subjects
Animals
Caenorhabditis elegans - metabolism
Caenorhabditis elegans Proteins - metabolism
Carrier Proteins - metabolism
Cytoplasm - metabolism
Nuclear Proteins - metabolism
Polyadenylation - physiology
RNA, Helminth - metabolism
RNA, Messenger - metabolism
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Summary:In this issue of Developmental Cell, Elewa et al. (2015) show that combinatorial action of RNA binding proteins modulates poly(A) tail length of maternal mRNAs, leading to asymmetric expression of a cell fate determinant in early C. elegans embryos. Genome-wide profiling suggests this mechanism may be widely used to establish cell identities.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Commentary-1
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2015.06.022