Comparative analysis of accumulation of chlorine e6 and hematoporphyrin derivatives in subpopulations of peripheral blood lymphocytes

We studied accumulation of porphyrin photosensitizers chlorine e6, hematoporphyrin, and their derivatives by different lymphocyte subpopulations. The intensity of staining of B lymphocytes and natural killer cells with photosensitizers was higher compared to T lymphocytes. T cell subpopulation diffe...

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Bibliographic Details
Published inBulletin of experimental biology and medicine Vol. 138; no. 2; pp. 158 - 162
Main Authors Savitskii, V P, Zorin, V P, Potapnev, M P, Potapenko, A Ya
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.08.2004
Subjects
B-Lymphocyte Subsets - metabolism
Hematoporphyrin Derivative - metabolism
Hematoporphyrin Photoradiation
Humans
Lymphocyte Subsets - metabolism
Porphyrins - metabolism
T-Lymphocyte Subsets - metabolism
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Summary:We studied accumulation of porphyrin photosensitizers chlorine e6, hematoporphyrin, and their derivatives by different lymphocyte subpopulations. The intensity of staining of B lymphocytes and natural killer cells with photosensitizers was higher compared to T lymphocytes. T cell subpopulation differed by their ability to bind photosensitizers. Relative accumulation of dimethyl esters of chlorine e6 and hematoporphyrin in cells surpassed that of nonesterified porphyrins.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0007-4888
1573-8221
DOI:10.1023/b:bebm.0000048375.50335.7b