Successful Use of EPOCH-R in 2 Young Adult Patients With Burkitt Lymphoma and Acute Kidney Injury: A Case Report

• Published in: Journal of pediatric hematology/oncology Vol. 41; no. 6; p. 498
• Main Authors: Ross, Savannah, Eisenman, Kristen, Maloney, Kelly W
• Format: Journal Article
• Language: English
• Published: United States 01.08.2019
• Subjects: Acute Kidney Injury - complications; Acute Kidney Injury - drug therapy; Acute Kidney Injury - pathology; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Burkitt Lymphoma - complications; Burkitt Lymphoma - drug therapy; Burkitt Lymphoma - pathology; Cyclophosphamide - administration & dosage; Down Syndrome - complications; Down Syndrome - drug therapy; Down Syndrome - pathology; Doxorubicin - administration & dosage; Etoposide - administration & dosage; Humans; Male; Prednisone - administration & dosage; Prognosis; Rituximab - administration & dosage; Vincristine - administration & dosage
• ISSN: 1536-3678
• DOI: 10.1097/MPH.0000000000001287

Pediatric Burkitt lymphoma has historically been treated with intensive methotrexate-based chemotherapy, which improves patient survival while causing severe toxicities. Young patients typically have better outcomes with intensive therapies, while adults and immunocompromised patients have higher toxicities and worse outcomes. Newer treatment regimens, including etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, rituximab (EPOCH-R), show promise for these patients. However, few studies exist to demonstrate efficacy and improved toxicity profile with EPOCH-R. We present 2 cases: a 25-year-old male with Down syndrome and an 18-year-old male with Burkitt lymphoma and significant renal injury who were successfully treated with EPOCH-R with minimal toxicities.