Chaperoned by Prebiotic Inorganic Polyphosphate Molecules: An Ancient Transcription-Independent Mechanism to Restore Protein Homeostasis

In this issue, Gray et al. (2014) elegantly demonstrate how cells utilize an oxidation-regulated pathway that depletes cellular ATP, lowers proteostatic burden, and leads to accumulation of prebiotic, inorganic polyphosphates with chaperone-like activity for stress protection.

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Bibliographic Details
Published inMolecular cell Vol. 53; no. 5; pp. 685 - 687
Main Author Kampinga, Harm H.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 06.03.2014
Subjects
Escherichia coli - metabolism
Escherichia coli Proteins - metabolism
Molecular Chaperones - metabolism
Polyphosphates - metabolism
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Summary:In this issue, Gray et al. (2014) elegantly demonstrate how cells utilize an oxidation-regulated pathway that depletes cellular ATP, lowers proteostatic burden, and leads to accumulation of prebiotic, inorganic polyphosphates with chaperone-like activity for stress protection.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Commentary-1
ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2014.02.023