Livers Transplanted From Donors After Cardiac Death Occurring in the ICU or the Operating Room Have Excellent Outcomes

• Published in: Transplantation proceedings Vol. 37; no. 2; pp. 1188 - 1193
• Main Authors: Olson, L., Kisthard, J., Cravero, L., Fung, J., Eghtesad, B., Savo, A., Levy, A., Polissar, N., Marks, W.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York, NY Elsevier Inc 01.03.2005; Elsevier Science
• Subjects: Adult; Bilirubin - blood; Biological and medical sciences; Cardiac Surgical Procedures - mortality; Cause of Death; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Heart Diseases - surgery; Humans; Intensive Care Units; Life Support Care; Liver Function Tests; Liver Transplantation - physiology; Medical sciences; Middle Aged; Patient Selection; Retrospective Studies; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Tissue and Organ Procurement - organization & administration; Tissue Donors; Tissue, organ and graft immunology; Treatment Outcome; Heart; Human; Prognosis; Digestive system; Liver; Mortality; Transplantation; Homotransplantation; Intensive care unit; Medicine; Treatment; Donor; Surgery; Operating room; Evolution; Graft; Death; Circulatory system
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2004.12.021

Increasing donor hospital cooperation with donation after cardiac death (DCD) requires the organ procurement organization (OPO) to use current withdrawal of life support (WLS) protocols. Hospital ICU nurses/physicians are comfortable performing the emotionally draining procedure of WLS in the ICU while OPOs are reluctant to accept these donors due to increased warm ischemia (WI). In our area, several hospitals will only allow WLS to occur in the ICU. This study compares liver outcomes from DCD donors where death occurred in the ICU (DCDICU) vs the OR (DCDOR). From March 2003 to June 2004, 34 DCD donors were recovered by our OPO. WLS occurred in the ICU for 26 donors (76%) and in the OR for 8 donors (24%). Thirteen of 26 DCDICU and 5 of 8 DCDOR livers were transplanted. Donor demographics, warm ischemic time, cold ischemic time, distance shipped, and recipient functions were analyzed. Eighteen livers were transplanted both locally and at distant transplant centers. Results are outlined in the Table 1. Although DCDICU donors averaged ∼4 minutes longer WI than DCDOR donors, short-term results for both groups were equivalent. These findings support using DCDICU livers. DCDICU donors have the potential to significantly improve donor hospital cooperation.