Teamwork in microtubule motors

Highlights • Can cell mechanics be understood in terms of the molecules that generate force? • How does single-molecule function of motors translate into their collective cellular function?. • Surprising reversal of roles: ‘good’ motors fail, but ‘bad’ motors excel as a team. • Dynein's gear-li...

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Bibliographic Details
Published inTrends in cell biology Vol. 23; no. 11; pp. 575 - 582
Main Authors Mallik, Roop, Rai, Arpan K, Barak, Pradeep, Rai, Ashim, Kunwar, Ambarish
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.11.2013
Subjects
cooperative forces inside cells
dynein
dynein gear
in vivo optical trapping
kinesin
Microtubules - metabolism
Molecular Motor Proteins - metabolism
organelle transport
Organelles - metabolism
Pathology
dynein
organelle transport
in vivo optical trapping
cooperative forces inside cells
kinesin
dynein gear
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Summary:Highlights • Can cell mechanics be understood in terms of the molecules that generate force? • How does single-molecule function of motors translate into their collective cellular function?. • Surprising reversal of roles: ‘good’ motors fail, but ‘bad’ motors excel as a team. • Dynein's gear-like response and catch bond may adapt it to work well in a team.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2013.06.003