Exosome-Mediated Metastasis: Communication from a Distance

• Published in: Developmental cell Vol. 49; no. 3; pp. 347 - 360
• Main Authors: Wortzel, Inbal, Dror, Shani, Kenific, Candia M., Lyden, David
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 06.05.2019
• Subjects: Animals; bone-marrow-derived cell; cancer; Cell Communication; Disease Progression; exosome; Exosomes - metabolism; Exosomes - pathology; extracellular matrix; extracellular vesicle; Fibroblasts - metabolism; Humans; immune cell; integrins; intercellular communication; metastasis; microvesicle; Neoplasm Invasiveness - pathology; Neoplasm Metastasis - pathology; Neoplasms - metabolism; Neoplasms - pathology; Neovascularization, Pathologic - pathology; pre-metastatic niche; Tumor Microenvironment; vascular leakiness; microvesicle; integrins; metastasis; immune cell; intercellular communication; pre-metastatic niche; vascular leakiness; cancer; bone-marrow-derived cell; exosome; extracellular vesicle; extracellular matrix

Metastasis, a critical phase of tumor progression, remains a primary challenge in treating cancer and a major cause of cancer mortality. Cell-cell communication via extracellular vesicles (exosomes and microvesicles) between primary tumor cells and the microenvironment of distant organs is crucial f...