Exosome-Mediated Metastasis: Communication from a Distance

Metastasis, a critical phase of tumor progression, remains a primary challenge in treating cancer and a major cause of cancer mortality. Cell-cell communication via extracellular vesicles (exosomes and microvesicles) between primary tumor cells and the microenvironment of distant organs is crucial f...

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Bibliographic Details
Published inDevelopmental cell Vol. 49; no. 3; pp. 347 - 360
Main Authors Wortzel, Inbal, Dror, Shani, Kenific, Candia M., Lyden, David
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 06.05.2019
Subjects
Animals
bone-marrow-derived cell
cancer
Cell Communication
Disease Progression
exosome
Exosomes - metabolism
Exosomes - pathology
extracellular matrix
extracellular vesicle
Fibroblasts - metabolism
Humans
immune cell
integrins
intercellular communication
metastasis
microvesicle
Neoplasm Invasiveness - pathology
Neoplasm Metastasis - pathology
Neoplasms - metabolism
Neoplasms - pathology
Neovascularization, Pathologic - pathology
pre-metastatic niche
Tumor Microenvironment
vascular leakiness
microvesicle
integrins
metastasis
immune cell
intercellular communication
pre-metastatic niche
vascular leakiness
cancer
bone-marrow-derived cell
exosome
extracellular vesicle
extracellular matrix
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Summary:Metastasis, a critical phase of tumor progression, remains a primary challenge in treating cancer and a major cause of cancer mortality. Cell-cell communication via extracellular vesicles (exosomes and microvesicles) between primary tumor cells and the microenvironment of distant organs is crucial for pre-metastatic niche (PMN) formation and metastasis. Here, we review work on the contribution of exosome cargo to cancer progression, the role of exosomes in PMN establishment, and the function of exosomes in organotropic metastasis. We also describe the clinical utility of exosomes. Metastasis remains a primary challenge in treating cancer. Exosome-mediated communication between primary tumor cells and the microenvironment of distant organs is crucial for pre-metastatic niche formation and metastasis. In this Review, Wortzel et al. consider the contribution of exosome cargos to cancer progression and describe their potential clinical utility.
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ISSN:1534-5807
1878-1551
1878-1551
DOI:10.1016/j.devcel.2019.04.011