Inhibition of hepatitis B virus production by Boehmeria nivea root extract in HepG2 2.2.15 cells

• Published in: World journal of gastroenterology : WJG Vol. 12; no. 35; pp. 5721 - 5725
• Main Authors: Huang, Kai-Ling, Lai, Yiu-Kay, Lin, Chih-Chien, Chang, Jia-Ming
• Format: Journal Article
• Language: English
• Published: United States Department of Life Sciences and Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan 30013, China%Department of Life Sciences and Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan 30013, China 21.09.2006; Department of Bioresources, Da-Yeh University, Changhua, Taiwan 515, China%Division of Research and Development, Development Center for Biotechnology, Xizhi City, Taipei County, Taiwan 221, China; Baishideng Publishing Group Co., Limited
• Subjects: Antiviral Agents - pharmacology; Boehmeria - chemistry; Carcinoma, Hepatocellular - drug therapy; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - virology; Cell Line, Tumor; Cytotoxins - pharmacology; DNA Replication - drug effects; DNA, Viral - genetics; DNA, Viral - metabolism; Gene Expression Regulation, Neoplastic - drug effects; Gene Expression Regulation, Viral - drug effects; Hepatitis B e Antigens - genetics; Hepatitis B e Antigens - metabolism; Hepatitis B Surface Antigens - genetics; Hepatitis B Surface Antigens - metabolism; Hepatitis B virus - drug effects; Hepatitis B virus - genetics; Hepatitis B virus - immunology; Hepatitis B virus - metabolism; Humans; Liver Neoplasms - drug therapy; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Liver Neoplasms - virology; Plant Extracts - analysis; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Plant Roots - chemistry; Rapid Communication; RNA, Viral - genetics; RNA, Viral - metabolism; Transcription, Genetic - drug effects; 乙型肝炎; 病毒感染; 肝炎病毒; Medicinal herb; Anti-hepatitis B virus; Antiviral agent; Hepatitis B virus; Boehmeria nivea; HepG2 2.2.15

AIM： To explore the anti-hepatitis B virus （HBV） effects of Boehmeria nivea （B. nivea） root extract （BNE） by using the HepG2 2.2.15 cell model system. METHODS： Hepatitis B surface antigen （HBsAg）, hepatitis B virus e antigen （HBeAg）, and HBV DNA were measured by using ELISA and real-time PCR, respec...