Sonication-Based Basic Protocol for Liposome Synthesis

Liposomes are spherical vesicles with a wide range of sizes from nano- to micrometer scale. For the past 7-8 decades, these vesicles have occupied the interest of a variety of scientists due to its physical, chemical, and mathematical properties and, to say the least, for its immense utility and pot...

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Bibliographic Details
Published inMethods in molecular biology (Clifton, N.J.) Vol. 1609; p. 255
Main Authors Mendez, Roberto, Banerjee, Santanu
Format Journal Article
LanguageEnglish
Published United States 01.01.2017
Subjects
Lipid Bilayers
Lipids
Liposomes - chemical synthesis
Liposomes - chemistry
Phospholipids
Sonication - methods
Ultraviolet Rays
Vesicle
Sonication
SUV
Lipid bilayer
Liposome
Drug delivery
Phospholipids
LUV
Lipid
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Summary:Liposomes are spherical vesicles with a wide range of sizes from nano- to micrometer scale. For the past 7-8 decades, these vesicles have occupied the interest of a variety of scientists due to its physical, chemical, and mathematical properties and, to say the least, for its immense utility and potential as delivery vehicles for toxic and nontoxic excipients into biological tissues. Methods related to selection of reagents for creation of specific liposomes of certain properties are beyond the scope of this chapter, but here, we would outline a simplistic protocol to prepare and qualify an uniform batch of simple liposome with basic cargo. This chapter will attempt to provide the reader with a starting point for this immensely potent tool to build upon the right kind of liposome, appropriate for their studies.
ISSN:1940-6029
DOI:10.1007/978-1-4939-6996-8_21