Uneven Braking Spins RNA Polymerase into a Pause

In this issue of Molecular Cell, Guo et al. (2018) and Kang et al. (2018) report structures of paused transcription complexes in which asynchronous translocation inhibits nucleotide addition, allowing for global rearrangements in RNA polymerase stabilized by RNA hairpin and NusA. In this issue of Mo...

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Bibliographic Details
Published inMolecular cell Vol. 69; no. 5; pp. 723 - 725
Main Authors Artsimovitch, Irina, Belogurov, Georgiy A.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.03.2018
Subjects
DNA-Directed RNA Polymerases - genetics
Escherichia coli - genetics
Escherichia coli Proteins
Nucleic Acid Conformation
RNA, Bacterial
Transcription, Genetic
Transcriptional Elongation Factors
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Summary:In this issue of Molecular Cell, Guo et al. (2018) and Kang et al. (2018) report structures of paused transcription complexes in which asynchronous translocation inhibits nucleotide addition, allowing for global rearrangements in RNA polymerase stabilized by RNA hairpin and NusA. In this issue of Molecular Cell, Guo et al. (2018) and Kang et al. (2018) report structures of paused transcription complexes in which asynchronous translocation inhibits nucleotide addition, allowing for global rearrangements in RNA polymerase stabilized by RNA hairpin and NusA.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Commentary-1
ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2018.02.013