Correlation between CD4, CD8 cell infiltration in gastric mucosa, Helicobacter pylori infection and symptoms in patients with chronic gastritis

• Published in: World journal of gastroenterology : WJG Vol. 11; no. 16; pp. 2486 - 2490
• Main Authors: Lu, Ai-Ping, Zhang, Sheng-Sheng, Zha, Qing-Lin, Ju, Da-Hong, Wu, Hao, Jia, Hong-Wei, Xiao, Cheng, Li, Shao, Jian, Hui
• Format: Journal Article
• Language: English
• Published: United States Institute of Basic Theory, China Academy of Traditional Chinese Medicine, Beijing 100700, China 28.04.2005; National Pharmaceutical Engineer Center for Herbal Solid Preparation, Nanchang 330047, Jiangxi Province, China%Beijing Traditional Chinese Medicine Hospital, Beijing 100007, China%Jiangxi Traditional Chinese Medicine Institute,Nanchang 330066, Jiangxi Province, China%Institute of Basic Theory, China Academy of Traditional Chinese Medicine, Beijing 100700, China%Tsinghua University, Beijing 100028, China%National Pharmaceutical Engineer Center for Herbal Solid Preparation, Nanchang 330047, Jiangxi Province, China; Baishideng Publishing Group Inc
• Subjects: Adolescent; Adult; Aged; Brief Reports; CD4; CD4-Positive T-Lymphocytes - immunology; CD8; CD8-Positive T-Lymphocytes - immunology; Chronic Disease; Female; Gastric Mucosa - immunology; Gastric Mucosa - microbiology; Gastric Mucosa - pathology; Gastritis - immunology; Gastritis - pathology; Helicobacter Infections - immunology; Helicobacter Infections - pathology; Helicobacter pylori; Humans; Male; Middle Aged; 传染病; 幽门螺杆菌; 慢性胃炎; 细胞渗透; 胃肿瘤; Helicobacter pylori infection; Chronic gastritis; Symptoms; Mucosal immune
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v11.i16.2486

AIM: To evaluate the correlation between CD4, CD8 cell infiltration in gastric mucosa, Helicobacter pylori ( H pylori)infection and symptoms or the assemblage of symptoms in cases with chronic gastritis. METHODS: Biopsy samples at the gastric antrum were obtained from 62 patients with chronic gastritis. CD4 and CD8 cell infiltration was evaluated by immunohistochemical assays on frozen sections of the biopsy samples. Fifteen symptoms referring to digestion-related activity and nondigestion related activity were observed. The correlation between lymphocyte infiltration and each symptom or symptom assemblage was analyzed by logistic regression and K-mean cluster methods. RESULTS: CD4 cell infiltrations in gastric mucosa were much more in patients with H pylori infection, while CD8 cell infiltrations were similar in patients with or without H pylori infection. Logistic regression analysis showed that the symptoms including heavy feeling in head or body (t= 2.563), and thirst (t= 2.478) were significantly related with CD4 cell infiltration in gastric mucosa (P<0.05), and cool limbs with aversion to cold were related with CD8 cell infiltration (t = 2.872, P<0.05). Further analysis showed that non-digestive related symptom assemblage could increase the predicted percentage of CD4 and CD8 cell infiltration in gastric mucosa, including lower CD4 infiltration by 12.5%, higher CD8 infiltration by 33.3%, and also non-Hpyloriinfection by 23.6%. K-means cluster analysis of all symptoms and CD4 and CD8 cell infiltration in gastric mucosa showed a similar tendency to increase the predicted percentage of CD4, CD8 cell infiltration and H pylori infection. CONCLUSION: Based on correlation between the gastric mucosa lymphocyte infiltration, H pylori infection and clinical symptoms, symptoms or symptomatic assemblages play an important role in making further classification of chronic gastritis, which might help find a more specific therapy for chronic gastritis,