METABOLIC EFFECTS OF INDUCED HYPOTENSION WITH TRIMETAPHAN AND SODIUM NITROPRUSSIDE

In two groups of patients undergoing induced hypotension with sodium nitroprusside or trimetaphan blood concentrations of lactate, pyruvate and standard bicarbonate did not differ significantly between the groups. In the nine patients who received trimetaphan there was a progressive, but statistical...

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Bibliographic Details
Published inBritish journal of anaesthesia : BJA Vol. 51; no. 9; pp. 875 - 879
Main Authors WlLDSMITH, J.A.W., DRUMMOND, G.B., MACRAE, W.R.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.09.1979
Oxford University Press
Subjects
Adolescent
Adult
Bicarbonates - blood
Ear, Middle - surgery
Female
Ferricyanides - pharmacology
Humans
Hypotension, Controlled
Lactates - blood
Male
Middle Aged
Nitroprusside - pharmacology
Pyruvates - blood
Trimethaphan - pharmacology
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Summary:In two groups of patients undergoing induced hypotension with sodium nitroprusside or trimetaphan blood concentrations of lactate, pyruvate and standard bicarbonate did not differ significantly between the groups. In the nine patients who received trimetaphan there was a progressive, but statistically non-significant, decrease in mean lactate. Nitroprusside (15 patients) was associated with a small increase in mean lactate, but at low dosage there was a small decrease. No relationship to dose rate of nitroprusside was found with these short-term infusions. It is concluded that sodium nitroprusside can be used safely for induced hypotension at doses less than 1.5 mg kg−1 and that simple blood-gas analysis is adequate for the assessment of toxic effects when greater doses are given.
Bibliography:ArticleID:51.9.875
istex:816132DC20E2190AC424A470257E6051DE9BE086
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ISSN:0007-0912
1471-6771
DOI:10.1093/bja/51.9.875