The Miami Experience With Almost 100 Multivisceral Transplants

• Published in: Transplantation proceedings Vol. 38; no. 6; pp. 1681 - 1682
• Main Authors: Tzakis, A.G., Kato, T., Nishida, S., Levi, D.M., DeFaria, W., Selvaggi, G., Weppler, D., Moon, J., Madariaga, J.R., David, A.I., Gaynor, J.J., Thompson, J., Hernandez, E., Tuteja, S., Tryphonopoulos, P., Ruiz, P.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York, NY Elsevier Inc 01.07.2006; Elsevier Science
• Subjects: Biological and medical sciences; Cause of Death; Florida; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Graft Rejection - epidemiology; Graft Survival; Humans; Immunosuppression - methods; Infection - epidemiology; Medical sciences; Postoperative Complications - classification; Retrospective Studies; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Survival Analysis; Time Factors; Tissue, organ and graft immunology; Transplantation, Homologous - immunology; Transplantation, Homologous - mortality; Treatment Outcome; Viscera - transplantation; Florida; Medicine; Experience; Treatment; Surgery; Graft; Multiorgan transplantation; Homotransplantation
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2006.05.015

We report our experience with 98 patients who received primary multivisceral transplantations. Three eras can be distinguished based on the evolution of technique, immunosuppression, and monitoring: August 1994 to December 1997 (first era); January 1998 to December 2000 (second era); and January 2001 to present (third era). Sixteen patients were transplanted during the first era, 18 during the second era, and 64 during the third era. Fifty-three patients are alive with a median follow-up of 37.5 months (range: 1 to 116 months). The leading cause of mortality was infection ( n = 17), followed by rejection ( n = 6). Seven patients required retransplantation and five of them subsequently died. The estimated 3-year survival was 25% ± 11% for era 1; 44% ± 12% for era 2; and 58% ± 7% for era 3. Additionally, 45.3% (29/64) of patients in the third era never developed rejection versus 23.5% (8/34) of patients in the first two eras combined. The percentage of patients who developed a moderate or severe rejection was significantly less in the third era compared with the first two eras combined, 31.6% (20/64) versus 67.6% (23/34). A comparison of the hazard rate of developing severe rejection showed a protective effect of the multivisceral graft ( P = .0001). In conclusion, multivisceral transplantation is indicated for patients with short bowel syndrome and extended abdominal catastrophies. Evolution in surgical techniques, immunosuppression, and monitoring have improved patient survival, which is now similar to that of other complex solid organ transplants.