Supportive CSF biomarker evidence to enhance the National Institute on Aging-Alzheimer's Association criteria for diagnosis of Alzheimer's type dementia – A study from Southern India

Highlights • CSF biomarkers as supportive evidence for the current diagnostic criteria of AD was assessed. • The ratio of p-tau/t-tau was significantly different between mild and moderate to severe AD. • p-tau/t-tau and p-tau/Aβ ratio are reliable indicators of severity of dementia.

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Bibliographic Details
Published inAsian journal of psychiatry Vol. 13; pp. 44 - 47
Main Authors Huded, Chandrashekar B, Bharath, Srikala, Chandra, S.R, Sivakumar, P.T, Varghese, Mathew, Subramanian, Sarada
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.02.2015
Subjects
Adult
Aged
Aged, 80 and over
Alzheimer disease
Alzheimer Disease - cerebrospinal fluid
Alzheimer Disease - diagnosis
Amyloid beta-Peptides - cerebrospinal fluid
Amyloid β
Biomarker
Biomarkers - cerebrospinal fluid
Cerebrospinal fluid
Female
Humans
India
Internal Medicine
Male
Middle Aged
National Institute on Aging (U.S.)
Peptide Fragments - cerebrospinal fluid
Phosphorylation
Psychiatry
Tau
tau Proteins - cerebrospinal fluid
United States
United States
India
Tau
Biomarker
Cerebrospinal fluid
Alzheimer disease
Amyloid β
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Summary:Highlights • CSF biomarkers as supportive evidence for the current diagnostic criteria of AD was assessed. • The ratio of p-tau/t-tau was significantly different between mild and moderate to severe AD. • p-tau/t-tau and p-tau/Aβ ratio are reliable indicators of severity of dementia.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1876-2018
1876-2026
DOI:10.1016/j.ajp.2014.10.007