Refractory Chronic Rhinosinusitis with Nasal Polyposis

Chronic rhinosinusitis with nasal polyposis (CRSwNP) represents a subset of chronic sinusitis with various causes. Some forms of the disease are driven by allergy, often in association with asthma. Refractory CRSwNP can be associated with cystic fibrosis and other clinical syndromes. More recent lit...

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Published inOtolaryngologic clinics of North America Vol. 50; no. 1; pp. 61 - 81
Main Authors Hull, Benjamin P., MD, MHA, Chandra, Rakesh K., MD
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.02.2017
Subjects
Allergic fungal sinusitis
Allergy
Asthma
Chronic Disease
Combined Modality Therapy - methods
Cystic fibrosis
Disease Management
Humans
Immunity, Innate - drug effects
Innate immunity
Nasal Polyps - diagnosis
Nasal Polyps - etiology
Nasal Polyps - therapy
Otolaryngology
Polyps
Rhinitis - diagnosis
Rhinitis - etiology
Rhinitis - therapy
Sinusitis - diagnosis
Sinusitis - etiology
Sinusitis - therapy
Superantigen
Surgery
Allergy
Superantigen
Innate immunity
Cystic fibrosis
Polyps
Allergic fungal sinusitis
Asthma
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Summary:Chronic rhinosinusitis with nasal polyposis (CRSwNP) represents a subset of chronic sinusitis with various causes. Some forms of the disease are driven by allergy, often in association with asthma. Refractory CRSwNP can be associated with cystic fibrosis and other clinical syndromes. More recent literature is presented regarding roles of innate immunity and superantigens. Effective treatment of CRSwNP requires careful endoscopic sinus surgery followed by an individualized treatment plan that often includes oral and topical steroids. Recidivism of polyps is common, and patients require long-term follow-up.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0030-6665
1557-8259
DOI:10.1016/j.otc.2016.08.006