Combined en bloc liver/pancreas transplantation in two different patients

Combined en bloc liver/pancreas transplantation (CLPT) was used primarily in the treatment of otherwise non-resectable upper abdominal malignancy. In fact, a more appropriate indication is in patients with liver disease and insulin-dependent diabetes mellitus (IDDM). Here, we report on two successfu...

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Published inWorld journal of gastroenterology : WJG Vol. 15; no. 20; pp. 2552 - 2555
Main Authors Chen, Zhi-Shui, Meng, Fan-Ying, Chen, Xiao-Ping, Liu, Dun-Gui, Wei, Lai, Jiang, Ji-Pin, Du, Dun-Feng, Zhang, Wei-Jie, Ming, Chang-Sheng, Gong, Nian-Qiao
Format Journal Article
LanguageEnglish
Published United States Institute of Organ Transplantation,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei Province,China 28.05.2009
The WJG Press and Baishideng
Subjects
Adult
Case Report
Humans
Liver Diseases - surgery
Liver Transplantation - methods
Male
Middle Aged
Pancreas Transplantation - methods
Liver cancer
Transplantation
Pancreas
Liver
Diabetes mellitus
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Summary:Combined en bloc liver/pancreas transplantation (CLPT) was used primarily in the treatment of otherwise non-resectable upper abdominal malignancy. In fact, a more appropriate indication is in patients with liver disease and insulin-dependent diabetes mellitus (IDDM). Here, we report on two successful cases of CLPT at our hospital. One was a patient with non-resectable advanced liver cancer. The recipient survived for 23 mo and finally died of recurrent tumor. The other was a patient with severe biliary complication after orthotopic liver transplantation and preoperative IDDM. We performed CLPT with a modified surgical technique of preserving the native pancreas. He is currently liver-disease- and insulin-free more than 27 mo post-transplant. Based on our experience in two cases of abdominal cluster transplantation, we describe the technical details of CLPT and a modification of the surgical procedure.
Bibliography:ObjectType-Case Study-2
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Author contributions: All of the co-authors performed the research; Meng FY wrote the paper.
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Correspondence to: Zhi-Shui Chen, MD, PhD, Key Laboratory of Organ Transplantation, Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China. zschen@tjh.tjmu.edu.cn
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.15.2552