Appropriate Antibiotic Therapy

Prescribing antibiotics is an essential component of initial therapy in sepsis. Early antibiotics are an important component of therapy, but speed of administration should not overshadow the patient-specific characteristics that determine the optimal breadth of antimicrobial therapy. Cultures should...

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Bibliographic Details
Published inEmergency medicine clinics of North America Vol. 35; no. 1; p. 25
Main Authors Allison, Michael G, Heil, Emily L, Hayes, Bryan D
Format Journal Article
LanguageEnglish
Published United States 01.02.2017
Subjects
Acute Kidney Injury - chemically induced
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - adverse effects
Anti-Bacterial Agents - therapeutic use
Humans
Obesity - complications
Sepsis - complications
Sepsis - drug therapy
Sepsis - microbiology
Time Factors
Antifungals
Resistance
Dosing
Obesity
Antibiotics
Acute kidney injury
Sepsis
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Summary:Prescribing antibiotics is an essential component of initial therapy in sepsis. Early antibiotics are an important component of therapy, but speed of administration should not overshadow the patient-specific characteristics that determine the optimal breadth of antimicrobial therapy. Cultures should be drawn before antibiotic therapy if it does not significantly delay administration. Combination antibiotic therapy against gram-negative infections is not routinely required, and combination therapy involving vancomycin and piperacillin/tazobactam is associated with an increase in acute kidney injury. Emergency practitioners should be aware of special considerations in the administration and dosing of antibiotics in order to deliver optimal care to septic patients.
ISSN:1558-0539
DOI:10.1016/j.emc.2016.08.003