Hepatitis B and Risk of Non-Hepatocellular Carcinoma Malignancy

Chronic hepatitis B infection (CHB) is a known risk factor for malignancy. Unlike hepatocellular carcinoma (HCC), less is known about the risk of non-HCC malignancy. However, epidemiology and pathologic evidence suggests a strong association between non-Hodgkin lymphoma and CHB. Data regarding the r...

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Bibliographic Details
Published inClinics in liver disease Vol. 20; no. 4; p. 693
Main Authors Kwok, Ryan M, Tran, Tram T
Format Journal Article
LanguageEnglish
Published United States 01.11.2016
Subjects
Bile Duct Neoplasms - diagnosis
Bile Duct Neoplasms - epidemiology
Bile Duct Neoplasms - etiology
Carcinogenesis
Global Health
Hepatitis B - complications
Humans
Incidence
Pancreatic Neoplasms
Pancreatic Neoplasms - diagnosis
Pancreatic Neoplasms - epidemiology
Pancreatic Neoplasms - etiology
Risk Factors
Non-Hodgkin lymphoma
Pancreatic adenocarcinoma
Chronic hepatitis B
Intrahepatic cholangiocarcinoma
Non–hepatocellular carcinoma malignancy
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Summary:Chronic hepatitis B infection (CHB) is a known risk factor for malignancy. Unlike hepatocellular carcinoma (HCC), less is known about the risk of non-HCC malignancy. However, epidemiology and pathologic evidence suggests a strong association between non-Hodgkin lymphoma and CHB. Data regarding the risk of other malignancies, such as pancreatic adenocarcinoma and intrahepatic cholangiocarcinoma, are mixed. Surveillance and appropriate treatment of infection and malignancy in these patients is essential. Further study of these associations is needed and may bring new insights in the pathogenesis and treatment of these diseases.
ISSN:1557-8224
DOI:10.1016/j.cld.2016.06.005