Update on Recurrent Respiratory Papillomatosis

• Published in: Otolaryngologic clinics of North America Vol. 52; no. 4; pp. 669 - 679
• Main Authors: Derkay, Craig S., MD, Bluher, Andrew E., MD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2019
• Subjects: Adult; Bevacizumab; Bevacizumab - therapeutic use; Child; Cost of Illness; HPV vaccine; Human papillomavirus (HPV); Humans; Otolaryngology; Papillomavirus Infections - economics; Papillomavirus Infections - epidemiology; Papillomavirus Infections - prevention & control; Papillomavirus Infections - therapy; Papillomavirus Vaccines; Quality of Life; Recurrent respiratory papillomas (RRP); Respiratory Tract Infections - economics; Respiratory Tract Infections - epidemiology; Respiratory Tract Infections - prevention & control; Respiratory Tract Infections - therapy; Surgery; Surgical Procedures, Operative; Recurrent respiratory papillomas (RRP); Human papillomavirus (HPV); HPV vaccine; Bevacizumab
• ISSN: 0030-6665; 1557-8259
• DOI: 10.1016/j.otc.2019.03.011

Recurrent respiratory papillomatosis (RRP) remains a challenging disease afflicting children and adults, resulting in an estimated $120 million per year in United States healthcare–related costs, with annual costs per patient approaching $60,000. Although the prevalence of RRP has declined, RRP remains the most common benign laryngeal neoplasm in children. RRP is unique in its high rate of multisite recurrence, its high burden on patient quality of life, and its high associated healthcare costs. This article summarizes current understanding of the natural history and quality of life burden of RRP, and basic science advancements in prevention and treatment.