Mechanical Ventilation and Bronchopulmonary Dysplasia

Mechanical ventilation is an important potentially modifiable risk factor for the development of bronchopulmonary dysplasia. Effective use of noninvasive respiratory support reduces the risk of lung injury. Lung volume recruitment and avoidance of excessive tidal volume are key elements of lung-prot...

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Bibliographic Details
Published inClinics in perinatology Vol. 42; no. 4; p. 781
Main Authors Keszler, Martin, Sant'Anna, Guilherme
Format Journal Article
LanguageEnglish
Published United States 01.12.2015
Subjects
Bronchopulmonary Dysplasia - prevention & control
Humans
Infant, Newborn
Infant, Premature
Lung - growth & development
Noninvasive Ventilation - methods
Oxidative Stress
Pulmonary Surfactants - therapeutic use
Respiration, Artificial - methods
Risk Factors
Tidal Volume
Bronchopulmonary dysplasia
Ventilator-associated lung injury
Volume-targeted ventilation
Mechanical ventilation
Lung-protective ventilation
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Summary:Mechanical ventilation is an important potentially modifiable risk factor for the development of bronchopulmonary dysplasia. Effective use of noninvasive respiratory support reduces the risk of lung injury. Lung volume recruitment and avoidance of excessive tidal volume are key elements of lung-protective ventilation strategies. Avoidance of oxidative stress, less invasive methods of surfactant administration, and high-frequency ventilation are also important factors in lung injury prevention.
ISSN:1557-9840
DOI:10.1016/j.clp.2015.08.006