Effects of praziquantel and oxamniquine on a Saudi Arabian strain of Schistosoma mansoni in mice

• Published in: Journal of helminthology Vol. 64; no. 1; p. 62
• Main Authors: Ghandour, A M, Banaja, A A, Shalaby, I M
• Format: Journal Article
• Language: English
• Published: England 01.03.1990
• Subjects: Administration, Oral; Animals; Dose-Response Relationship, Drug; Mice; Nitroquinolines - therapeutic use; Oxamniquine - administration & dosage; Oxamniquine - therapeutic use; Praziquantel - administration & dosage; Praziquantel - therapeutic use; Saudi Arabia; Schistosomiasis mansoni - drug therapy; Schistosomiasis mansoni - prevention & control; Saudi Arabia
• ISSN: 0022-149X
• DOI: 10.1017/S0022149X00011895

The prophylactic and curative effects of praziquantel and oxamniquine on a Saudi Arabian strain of Schistosoma mansoni in MF-1 mice were assessed. The drugs were administered orally. At 240 mg/kg praziquantel, there was a reduction of 89.1% in adult worm recovery and a marked reduction in tissue deposited eggs. The reduction in adult worm recovery after dosing with 50 mg/kg oxamniquine was 89.2%. At low doses (40 mg/kg praziquantel and 30 mg/kg oxamniquine) administered at 11 days, 5 days and 3 h before and 5, 21 and 49 days after infection, the reduction in adult worm recovery was 0.0%, 65.1%, 58.8%, 33.6%, 0.0% and 76.0% for praziquantel and 0.0%, 66.0%, 60.0%, 41.3%, 10.8% and 79.0% for oxamniquine. Numbers of lung schistosomula and the size of hepatic granulomata were also reduced.