Distinct alterations in motor & reward seeking behavior are dependent on the gestational age of exposure to LPS-induced maternal immune activation

• Published in: Brain, behavior, and immunity Vol. 63; pp. 21 - 34
• Main Authors: Straley, Megan E, Van Oeffelen, Wesley, Theze, Sarah, Sullivan, Aideen M, O’Mahony, Siobhain M, Cryan, John F, O’Keeffe, Gerard W
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.07.2017
• Subjects: Allergy and Immunology; Animals; Dopamine - metabolism; Dopaminergic; Dopaminergic Neurons - immunology; Dopaminergic Neurons - physiology; Female; Fetal programming; Gestational Age; Inflammation - immunology; Lipopolysaccharide; Male; Maternal immune activation; Midbrain; Motor Activity - immunology; Motor Activity - physiology; Motor behavior; Neuron; Offspring behavior; Parkinson’s disease; Pregnancy; Prenatal Exposure Delayed Effects - immunology; Prenatal Exposure Delayed Effects - physiopathology; Psychiatry; Rats; Rats, Sprague-Dawley - immunology; Reward; Reward behavior; Substantia Nigra - immunology; Substantia Nigra - metabolism; Ventral Tegmental Area - immunology; Ventral Tegmental Area - metabolism; Maternal immune activation; Neuron; Motor behavior; Reward behavior; Offspring behavior; Lipopolysaccharide; Midbrain; Fetal programming; Parkinson’s disease; Dopaminergic
• ISSN: 0889-1591; 1090-2139
• DOI: 10.1016/j.bbi.2016.06.002

Highlights • In utero inflammation is implicated in neurological disorders that affect dopamine. • In utero LPS exposure alters dopaminergic-driven behaviour in affected offspring. • The type of behaviour affected depends on the gestational age of exposure. • Gestational age may determine whether LPS-induced MIA alters behaviour.