Chromothripsis Detection and Characterization Using the CTLPScanner Web Server

Accurate detection of chromothripsis event is important to study the mechanisms underlying this phenomenon. CTLPScanner ( http://cgma.scu.edu.cn/CTLPScanner/ ) is a web-based tool for identification and annotation of chromothripsis-like pattern (CTLP) in genomic array data. In this chapter, we illus...

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Bibliographic Details
Published inMethods in molecular biology (Clifton, N.J.) Vol. 1769; p. 265
Main Authors Yang, Jian, Liu, Bo, Cai, Haoyang
Format Journal Article
LanguageEnglish
Published United States 01.01.2018
Subjects
Chromothripsis
Comparative Genomic Hybridization
Computational Biology - methods
Databases, Genetic
Polymorphism, Single Nucleotide
Software
Web Browser
Chromosome pulverization
Array CGH
Metadata analysis
CTLPScanner
Chromothripsis detection
SNP array
Web server
Online AccessGet more information

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Summary:Accurate detection of chromothripsis event is important to study the mechanisms underlying this phenomenon. CTLPScanner ( http://cgma.scu.edu.cn/CTLPScanner/ ) is a web-based tool for identification and annotation of chromothripsis-like pattern (CTLP) in genomic array data. In this chapter, we illustrate the utility of CTLPScanner for screening chromosome pulverization regions and give interpretation of the results. The web interface offers a set of parameters and thresholds for customized screening. We also provide practical recommendations for effective chromothripsis detection. In addition to the user data processing module, CTLPScanner contains more than 50,000 preprocessed oncogenomic arrays, which allow users to explore the presence of chromothripsis signatures from public data resources.
ISSN:1940-6029
DOI:10.1007/978-1-4939-7780-2_17