Epinephrine promotes COX-2-dependent immune suppression in myeloid cells and cancer tissues

• Published in: Brain, behavior, and immunity Vol. 62; pp. 78 - 86
• Main Authors: Muthuswamy, Ravikumar, Okada, Nana J, Jenkins, Frank J, McGuire, Kandace, McAuliffe, Priscilla F, Zeh, Herbert J, Bartlett, David L, Wallace, Callen, Watkins, Simon, Henning, Jill D, Bovbjerg, Dana H, Kalinski, Pawel
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.05.2017
• Subjects: Allergy and Immunology; Animals; Breast cancer; cAMP; Celecoxib - pharmacology; Cell Proliferation - drug effects; Colon cancer; CTLs; Cyclooxygenase 2 - metabolism; Cyclooxygenase 2 Inhibitors - pharmacology; Epinephrine; Epinephrine - pharmacology; Female; Humans; IDO; Immune suppression; Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism; Inflammation; Interleukin-10 - metabolism; Macrophages - drug effects; Macrophages - immunology; Macrophages - metabolism; Mammary Neoplasms, Experimental - immunology; Mammary Neoplasms, Experimental - metabolism; Mice; Myeloid Cells - drug effects; Myeloid Cells - immunology; Myeloid Cells - metabolism; Prostaglandins; Psychiatry; Stress; Suppressive macrophages; Epinephrine; Suppressive macrophages; Prostaglandins; Colon cancer; IDO; CTLs; Immune suppression; Inflammation; Breast cancer; cAMP; Stress
• ISSN: 0889-1591; 1090-2139; 1090-2139
• DOI: 10.1016/j.bbi.2017.02.008

Highlights • Inflammation promotes catecholamine-driven immune suppression. • COX-2 blockade prevents the induction of suppressive factors by epinephrine. • COX-2 blockade counteracts suppressive activity of epinephrine-treated macrophages. • Our data suggest that COX-2 blockade may reduce the immunosuppressive effects of psychologic stress.