Insecticide discovery: An evaluation and analysis

• Published in: Pesticide biochemistry and physiology Vol. 107; no. 1; pp. 8 - 17
• Main Author: Sparks, Thomas C.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2013
• Subjects: Chemical Industry - economics; Chemical Industry - history; Costs and Cost Analysis; Development costs; History, 20th Century; History, 21st Century; Insecticide Resistance; Insecticide resistance management; Insecticides - economics; Insecticides - history; Pesticide discovery – time needed; Research - economics; Research - history; Screening success; Vertebrate selectivity ratio; Vertebrate selectivity ratio; IMI; VSR; IRM; IPM; Development costs; Pesticide discovery – time needed; IRAC; Insecticide resistance management; HCH; MTD; Screening success
• ISSN: 0048-3575; 1095-9939
• DOI: 10.1016/j.pestbp.2013.05.012

[Display omitted] •The number of US & EU R&D-based companies involved in pesticide discovery is declining.•The cost of discovering and developing a new pesticide is getting more expensive.•Screening success rates have hit a plateau.•Mean time to discovery (MTD) for a broad sampling of insecticides is 3.7–4.2years.•The is no advantage to using competitor patent versus de novo efforts in MTD. There is an on-going need for the discovery and development of new insecticides due to the loss of existing products through the development of resistance, the desire for products with more favorable environmental and toxicological profiles, shifting pest spectrums, and changing agricultural practices. Since 1960, the number of research-based companies in the US and Europe involved in the discovery of new insecticidal chemistries has been declining. In part this is a reflection of the increasing costs of the discovery and development of new pesticides. Likewise, the number of compounds that need to be screened for every product developed has, until recently, been climbing. In the past two decades the agrochemical industry has been able to develop a range of new products that have more favorable mammalian vs. insect selectivity. This review provides an analysis of the time required for the discovery, or more correctly the building process, for a wide range of insecticides developed during the last 60years. An examination of the data around the time requirements for the discovery of products based on external patents, prior internal products, or entirely new chemistry provides some unexpected observations. In light of the increasing costs of discovery and development, coupled with fewer companies willing or able to make the investment, insecticide resistance management takes on greater importance as a means to preserve existing and new insecticides.